ABSTRACT
Background: In the newborn low platelet count is a common finding in both preterm and term newborn. It has been estimated that as many as 22% of all new borns admitted to NICU develop low platelet counts. A platelet count of less than 150,000/mL is defined as thrombocytopenia irrespective of the age of the individual.Methods: All the neonates underwent necessary blood investigations like Complete blood counts, (including platelet counts, HB estimation, Red cell indices and PCV), Capsular Polysaccharide - reactive protein. (CRP), Peripheral Smear study, Blood culture, BT, CT, PT, aPPT, Anti-platelet Antibodies.Results: The prevalence of thrombocytopenia in our study was 28%. The proportion of severe thrombocytopenia among the neonatal thrombocytopenia, 11.2% in our study.Conclusions: It can be concluded that thrombocytopenia is very much common in among our NICU admissions. Septicemia is its most important and most common cause.
ABSTRACT
Among the chemical hazards, heavy metal like nickel (Ni) is considered to be a serious one. It induces severe liver and kidney damage by altering several marker enzymes and ascorbate-cholesterol metabolism. The objective of the study was to investigate the possible protective role of α-tocopherol on NiSO4 (Ni II) exposed alteration of hematological parameters, markers of liver and kidney functions, hepatic and renal antioxidant defense system in male albino rats. We have studied the effects of α-tocopherol supplementation on nickel sulfate induced alteration of body weight, hematology, liver and kidney toxicity markers (SGOT, SGPT, total protein, urea, creatinine) and hepatic and renal antioxidant defense system of male albino rats. Nickel toxicity results in decreased body weight gain and relative liver and kidney weight. Nickel treatment also resulted in alteration of hematological parameters along with increased liver and kidney toxicity markers. Nickel sulfate administration significantly increased the level of lipid peroxides and decreased antioxidant enzyme activities in hepatic and renal tissue. Simultaneous treatment with á-tocopherol exhibited a possible protective role on the toxic effect of nickel on body and organ weights, hematological parameters, SGPT activity and improved tissue antioxidant defense system. α-tocopherol, may partially prevent nickel induced alteration of hematological and biochemical parameters as well as have amelioratic effects on nickel induced alteration of antioxidant status of liver and kidney.
ABSTRACT
Heavy metals are stable environmental contaminants, causing various alterations in target tissues. Garlic has some beneficial effect in preventing heavy metal induced various alteration. The objective was to investigate the possible protective role of fresh aqueous homogenate of garlic on hematology, erythrocyte antioxidant defense system in male albino rats treated with NiSO4 and K2Cr2O7. Rats were divided into six groups. Group I was untreated control. Group II was given aqueous homogenate of garlic (orally). Group III was administered with nickel sulfate (i.p). Group IV was given NiSO4 and garlic simultaneously. Group V was administered with K2Cr2O7 (i.p). Group VI were treated simultaneously with K2Cr2O7 and garlic. RBC, WBC, platelet count, PCV%, hemoglobin concentration decreased significantly and clotting time increased significantly after nickel treatment. After chromium treatment all the values decreased except clotting time. Increased malondialdehyde and glutathione level after nickel and chromium treatment was observed. Also erythrocyte superoxide dismutase, glutathione peroxidase and catalase activities significantly increased after nickel and chromium treatment. Simultaneous garlic supplementation exhibited protective role to combat nickel toxicity, whereas no such beneficial effects were observed for chromium (VI). Garlic may partially prevent nickel and chromium induced alteration but such ameliorated effects as an antioxidant is only restricted on nickel induced alteration.
ABSTRACT
The present study was undertaken to establish short term memory status in Bipolar disorder cases as compared with normal age and sex matched control group in Bijapur (Karnataka). Results showed that a significant decrease in short term memory status in bipolar disorder cases as compared to their control group .Loss of attention, decreased processing speed and executive function patterns may be the probable causes of such observations.
ABSTRACT
The optimal availability of immune cells in the peripheral blood stream of women plays a critical role in their response to disease and therapeutic interventions. Interaction between the reproductive and immune system plays an important immunoregulatory role. This study was designed to examine the impact of different phases of menstrual cycle on the blood leukocytes. Twenty-four healthy women in their reproductive age group and having regular menstrual cycle were studied during menstrual, proliferative and secretary phases of menstrual cycle. Total leukocyte count, absolute and differential counts of neutrophils, lymphocytes and mixed cells (includes eosinophils, basophils and monocytes) were analyzed. Results showed that the variations in the different types of leukocytes during different phases of menstrual cycle were not statistically significant. No significant inter group difference, except for the significant decrease in differential lymphocyte percentage in proliferative phase as compared to menses were observed.
Subject(s)
Adolescent , Female , Humans , Leukocyte Count , Menstrual Cycle/blood , Young AdultABSTRACT
This study aims to develop Peak Expiratory Flow Rate (PEFR) predictors for Karnataka Muslim male and female subjects of aged 18 to 20 years. PEFR was recorded in a standing position using mini Wright Peak Flow Meter on one hundred and four (104) healthy male and sixty one (61) healthy female subjects. Anthropometrical measurements i.e. height, weight, body surface area and body mass index were calculated. Statistically significant correlation were found in both sexes between PEFR and standing height (male, r = 0.94, P < 0.001; female, r = 0.95, P < 0.001), weight (male, r = 0.56, P < 0.001; female, r = 0.70, P < 0.001) and body surface area (male, r = 0.68, P < 0.001; female, r = 0.57, P < 0.001). The correlation between PEFR and body mass index were not found statistically significant in both sexes (male, r = 0.081; female, r = 0.17). The prediction equation for Karnataka male and female Muslim subjects (aged 18 to 20 years) based on height, weight and body surface area and multiple regression equation based on all those physical parameters have been developed (PEFR (l/m) (male) = 1.7304 x height + 0.155 x weight + 140.45 x BSA + 5.02; PEFR (l/m) (female) = 2.0448 x height--16.08 weight + 664.697 x BSA--101.24).